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After two years, homocysteine levels in those who received a supplement with 200 mcg of folic acid, 10 mcg of B 12 , and 10 mg of B 6 had decreased by 2.4 mol/L, or about 17%, more than placebo, and bone mineral density loss had slowed in a subset of participants with low baseline B 12 status

Ziegler, D., Duan, W

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AOD-9604 received FDA Investigational New Drug status for obesity trials in the early 2000s but was never approved