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For example, the Rotterdam criteria permit a phenotype defined by ovulatory dysfunction and PCOM in the absence of hyperandrogenism, whereas the NIH criteria require hyperandrogenism together with ovulatory dysfunction

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Additionally, growing evidence connects gut dysbiosis and mitochondrial dysfunction to neurodegenerative disorders such as Parkinsons disease and Alzheimers disease, highlighting the importance of this bidirectional relationship in maintaining neuronal health

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10.1146/annurev.biochem.76.060305.150444 23 DainaA.MichielinO.ZoeteV