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PubMed Chang CH, et al
Metformin for the treatment of the polycystic ovary syndrome
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confirmed that intranasal Semax application induces rapid, gene-specific and region-specific neurotrophin mRNA changes across the rat brain including BDNF upregulation in the hippocampus, brainstem, and cerebellum establishing a comprehensive transcriptional neurotrophin signature that goes beyond a single brain region or gene target
It also upregulates over 4,000 genes involved in tissue repair, angiogenesis, and antioxidant defense while downregulating pro-inflammatory and pro-fibrotic pathways
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