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Next-generation candidates like Novos CagriSema or Amgens MariTide will need to demonstrate meaningful advantages in cardiovascular outcomes, NASH or metabolic disease to command better pricing

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Start your intake What the triple-agonist mechanism is and how it differs from dual agonists Retatrutide activates three receptors at once: GLP-1 (appetite suppression and insulin response), GIP (insulin response and adipose handling, the receptor tirzepatide adds on top of GLP-1), and glucagon (energy expenditure and hepatic fat metabolism)