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Phase 2 trial dosing used once-weekly subcutaneous injections with gradual escalation from 1 mg up to 12 mg to minimise gastrointestinal side effects

Analysis of covariance (ANCOVA) was used to analyze the primary endpoint

14 The patient underwent computed tomography (CT) to assess epicardial adipose tissue (EAT) attenuation and peri coronary adipose tissue (PCAT) attenuation, measures indicative of cardiac risk

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PubMed Central, doi:10.1038/sj.bjc.6604105

PubMed Clayton, A.H., Althof, S.E., Kingsberg, S., DeRogatis, L.R., Kroll, R., Goldstein, I., Kaminetsky, J., Spana, C., Lucas, J., Jordan, R., & Portman, D.J