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Impact of baseline characteristics and beta-cell function on the efficacy and safety of subcutaneous once-weekly semaglutide: a patient-level, pooled analysis of the SUSTAIN 15 trials

An experimental model of GLP-1R knockout mice (GLP-1R-/-) [37] demonstrated that (GLP-1R-/-) mice exhibited only modest decreases in gonadal weight, while females exhibited delayed puberty, but subsequent fertility and sex-steroid secretion were normal

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