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Key points 2 chromatography Super skids delivered in fast-track mode 19 new skids and 5 revamped modules, including 43 new vessels plus 13 reused vessels integrated into the new line From more than 9000 engineering hours to reach accelerated milestones to qualification readiness through FAT, SAT, IQ and OQ Modular design supporting fast installation and limited disruption, as well as full hygienic and GMP aligned fabrication for peptide processing scope of work, EQUIPMENT AND SERVICES SUPPLIED Engineering & prefabrication: 3D design of a section within a complete GLP1 process line, modular skid engineering including upstream buffer preparation and downstream purification, tank farm design for vessels from 200 L to 10000 L, prefabrication of hygienic piping and structural modules Utilities & hygienic design: integration of purified water, WFI and pure steam, clean compressed air and utility distribution panels, fully hygienic piping ensuring thermal stability and reliable cleaning cycles Equipment supply and integration: delivery of superskids and process skids fully wired and tested, assembly of all vessels, manifolds and connection points, integration of reused equipment with updated instrumentation Qualification and commissioning: FAT and SAT completed on skids, superskids and vessels IQ and OQ documentation with traceability, support during commissioning and handover to operations teams

Patients received once-weekly Ozempic 0.5mg or 1 mg, or placebo, in addition to standard of care

NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes

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