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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
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2008 [cited 2020 Apr 29];24(10):294352
Declining estrogen affects thermoregulation (hot flashes), mood regulation, and even melatonin receptor sensitivity
Its mechanism is thought to specifically stimulate lipolysis (the breakdown of fat) without affecting insulin sensitivity or cell proliferation
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