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Mechanistically, it activates Nrf2 and its nuclear translocation, thereby enhancing the expression of downstream antioxidant genes to relieve oxidative stress
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6b), MB07811, a liver-targeted TR agonist could enhance insulin secretion and reduce glucose levels independent of weight loss in non-obese mice (Fig
Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells
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The approach begins with a detailed history of concussion, blast exposure, repetitive head impacts, behavioral change, medication use and endocrine symptoms
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