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Description

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demonstrated that elevated TIPE2 expression in NK cells correlates with NK cell exhaustion, contributing to poor prognoses in both human and mouse cancer models

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206 Activation is typically initiated by upstream receptor tyrosine kinases (RTKs) or G proteincoupled receptors (GPCRs), which trigger PI3K to convert PIP2 into PIP3, thereby recruiting and activating AKT

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For example, in humans copper/zinc SOD is present in the cytosol, while manganese SOD is present in the mitochondrion

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