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Furthermore, despite patients euthyroid status, multiple symptoms were still much more serious in HT patients than in healthy controls, including the symptoms related to digestive system (abdominal distension, constipation, and diarrhea), circulatory system (chest tightness), endocrine system (chilliness, gain weight, and facial edema), neuropsychiatric system (forgetfulness, anxiety, depressed, fatigue, insomnia, irritability, and indifferent), movement system (joint pain and swelling) and mucocutaneous system (dry skin, pruritus, and hair loss) (Table 4)

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