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Yesmedication works best with nutrition and activity changes
For glycemic control, a published comment concluded that tirzepatide microdosing at 2.5 mg resulted in a 15% reduction in HbA1c levels, indicating metabolic improvement even at modest exposures, as noted in a comment by Kom et al
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46 That dedicated kidney outcomes study, involving over 3500 patients with both T2D and established chronic kidney disease, demonstrated that once-weekly subcutaneous semaglutide 1.0 mg significantly reduced the primary composite renal outcome (including kidney failure onset, a 50% persistent decline in estimated glomerular filtration rate (eGFR), or renal/cardiovascular death) compared with placebo
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