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The two strategies are therefore not substitutes, and they have very different evidence profiles

Conversely, nicotine may exert paradoxical inhibitory effects by activating immune pathways and inducing apoptosis, such as through stimulation of immature dendritic cells via PI3K/Akt signaling and modulation of caspase-3 and Cyclin B1 expression through 7-nAChR signaling [36]

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One example is the Jarisch-Herxheimer reaction, which may occur in those treated for syphilis or Lyme disease