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In a 6-month cohort of adults with moderate-to-severe psoriasis and obesity treated with weekly semaglutide, investigators observed clinically meaningful improvements in Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI), alongside weight loss and better metabolic parameters
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However, FFAR3 is much more enriched in L-cells of the small intestine (191, 193)
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Any minor side effects, such as mild fatigue or water retention, often subside after the body adjusts to the therapy
Biol Psychiatry 78(10):702710 Kursun O, Yemisci M, van den Maagdenberg AMJM, Karatas H (2021) Migraine and neuroinflammation: the inflammasome perspective
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