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doi:10.1016/j.bcp.2016.08.015
The combination is possible for some patients, but it requires careful planning because GLP-1 drugs already reduce appetite and slow stomach emptyingadding fasting on top can create new challenges around nutrition, energy levels, and medication absorption
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The GLP-1 rebound effect is a well-documented phenomenon: patients who lose weight purely on medication, without changing their eating habits or lifestyle, often regain the weight (and sometimes more) when they stop
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