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Nausea, in particular, correlates more strongly with peak concentration than with average drug exposure

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On the other hand, bioavailability issues may hinder oral glutathione supplementation (more on this later)

2022 The major difference between these agents lies in canagliflozin, which is less selective for SGLT2 over SGLT1 and is metabolized primarily in the liver (compared to kidneys), and sotagliflozin, which inhibits both SGLT1 and SGLT2

& Zoccali, C