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However, this mechanism of action can significantly affect digestive function, making dietary fibre an important consideration for patients on these therapies

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Important safety considerations when using these supplements together include: Drug interactions : Berberine may potentially interact with numerous medications, including antidiabetic drugs (increasing hypoglycaemia risk), anticoagulants, and medications metabolised by CYP450 enzymes (such as ciclosporin and certain statins)

However, due to discrepancies in findings from clinical trials, real-world data, and fundamental research, definitive recommendations for diabetic retinopathy screening prior to GLP-1 RA treatment initiation remain elusive

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