33 , e12953 (2021)
~ GSH(Glutathione)L-cysteineL-glutamateL-glycine 3 No.1 No.2 No.3 (GSH)(GSSG)GSH 60() (1)- 250 1111 4 : /() (334) () 04-23113199 40743252 B-180466009-00000-2 1000
They showed better effects in improving mouse motor function scores, promoting the repair and regeneration of synapses or dopaminergic neurons (TH+, GDNF, synaptophysin), and inhibiting neuroinflammatory responses (IBA-1, IL-2) compared to liraglutide and DA-JC1, highlighting the advantage of targeting more sites
This premise is reinforced by the discovery that different immune cells, including B and T lymphocytes, as well as myeloid-lineage cells such as monocytes, eosinophils, and neutrophils, express GLP-1Rs ( 3.1 Innate and adaptive immune response In rat models of systemic inflammation, a GLP-1 RA, exendin, significantly lowered pro-inflammatory cytokine levels, including IL-1, IL-6, TNF-, and interferon-gamma (IFN-) ( in vitro studies, GLP-1 RAs have demonstrated the capacity of promoting an anti-inflammatory state by influencing immune cell differentiation
But is it something to worry about
Medical guidelines advise stopping GLP-1 drugs at least one or two months before pregnancy, and "our study cannot on its own change such recommendations," said Dr