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Add in roughly a dozen tendons, multiple ligaments, the median nerve, and various blood vessels all packed into a compact space, and you begin to see why wrist problems are so prevalent
This has important clinical consequences, such as the lack of biological markers [7] and the hindered development of targeted pharmacological treatments
20 , e201023222416 (2024)
IGF-1 displays more binding sites for SHP2 (a phosphatase related to growth) and seems more prone to recruit Cbl [121] (an E3 ligase that targets the receptor for ubiquitination and destruction) and thus may explain a different regulatory mechanism not mediated by serine phosphorylation, and thus not so sensitive to metabolic derangements
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